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This Osavi supplement combines four ingredients. The main ingredient is reduced L-glutathione, the reduced form of glutathione. It also contains N-acetyl-L-cysteine (NAC), L-ornithine L-aspartate (LOLA) and concentrated milk thistle extract. Each daily dose of two capsules provides 250 mg of glutathione, 250 mg of LOLA, 190 mg of NAC and 125 mg of milk thistle extract. The bottle contains 60 capsules, which is enough for about two months at the recommended daily dose of two capsules.
Glutathione is a substance that your body produces itself. It consists of three amino acids: glutamate, cysteine and glycine. Together they form a small protein, a tripeptide. What many people do not know is that glutathione exists in two forms. The reduced form is abbreviated as GSH. This product contains reduced L-glutathione. In addition to glutathione, the formula also contains NAC, more about that below.
N-acetyl-L-cysteine, or NAC for short, is an acetylated form of the amino acid cysteine. Cysteine is one of the three amino acids that make up glutathione. With 190 mg per daily dose, NAC is on the modest side in this product compared to standalone NAC supplements, which often contain 600 mg or more per serving.
LOLA stands for L-ornithine L-aspartate, a combination of two amino acids. Ornithine and aspartate are amino acids that are also found in high-protein foods. Each daily dose of this product contains 250 mg of LOLA.
The fourth ingredient is milk thistle seed extract, standardised to at least 80% silymarin. Silymarin is a complex of plant substances, including silybin and isosilybin. Milk thistle has long been used in European herbal tradition. Milk thistle supports normal liver function.* Milk thistle may also contribute to digestion.* The 20:1 extract means that twenty times as much plant material was used to make the extract. You therefore get a concentrated form. Each daily dose provides 125 mg of extract, of which at least 100 mg is silymarin.
This Osavi product combines four ingredients: reduced L-glutathione, NAC, LOLA and milk thistle extract. The capsules are vegan, gluten-free and free from soy and lactose. Anyone looking for glutathione, NAC, LOLA and milk thistle in one capsule will find a convenient combination here, albeit in modest doses per ingredient.
*Health claim awaiting European approval.
This product combines reduced L-glutathione, N-acetyl-L-cysteine (NAC), L-ornithine L-aspartate (LOLA), and milk thistle extract with silymarin in one vegan capsule.
NAC is a form of the amino acid cysteine, one of the three building blocks of glutathione. Per daily dose, this product contains 190 mg NAC alongside 250 mg reduced L-glutathione.
The milk thistle seed extract in this product is standardised to a minimum of 80% silymarin and has an extract ratio of 20:1. This means that twenty times the amount of plant material was used to make the extract. Per daily dose, you get a minimum of 100 mg of silymarin.
The capsules are plant-based (hydroxypropyl methylcellulose) and the product is suitable for vegans. It contains no sugar, gluten or lactose.
* Percentage van de referentie inname volgens Verordening (EU) Nr. 1169/2011.
** Reference intake unknown.
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Reduced L-glutathione (GSH) is the reduced form of glutathione, a small protein that your body produces itself from three amino acids: glutamate, cysteine, and glycine. "Reduced" is a chemical designation for the form of the molecule (GSH).
NAC is a form of the amino acid cysteine, one of the three building blocks of glutathione. Therefore, both ingredients are often combined in a single formula. In this product, you get 250 mg of reduced L-glutathione and 190 mg of NAC per daily dose.
LOLA stands for L-ornithine L-aspartate, a combination of two amino acids. Ornithine and aspartate are also found in high-protein foods. This product contains 250 mg of LOLA per daily dose.
That depends on what you expect. The 250 mg of glutathione per daily dose is at the lower end of the usual range (250–1000 mg per day). NAC at 190 mg per daily dose is modest compared to standalone NAC supplements, which often provide 600 mg or more per serving. This product is a combination of four ingredients, with a modest amount of each. Those looking for higher dosages of a single ingredient are better off with a standalone supplement.
Glutathione is a tripeptide, a small protein made up of three amino acids. Your stomach and intestines contain enzymes that break down proteins and peptides, so some of it is split before it reaches your bloodstream. This applies to all oral forms.
Individual glutathione capsules usually contain only reduced L-glutathione, often in higher doses per capsule (500-1000 mg). A combination formula like this one also includes NAC, LOLA, and milk thistle extract, for a total of four ingredients. The downside is that the dosage of each ingredient is lower. The advantage is that you get four ingredients in one capsule, without having to buy four separate bottles. The choice depends on your goal: do you want as much glutathione as possible per capsule, or a more broadly formulated supplement?
